منابع مشابه
Translating Translational Biomedicine for Environmental Health
There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, where it is controlled by several trophic factors and neuroactive molecules. Neurogenesis is involved in ...
متن کاملTranslating Translational Research into Global Health Gains
Last month, the United States Supreme Court struck down a patent claim by Myriad Genetics on the BRCA1 and BRCA2 genes [1]. The case, Association for Molecular Pathology v. Myriad Genetics , considered whether genes isolated in the lab are ''products of nature'' that may not be patented or are ''human-made inventions'' that would be eligible for patent protection. In its decision, the Court dis...
متن کاملSignal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation
In eukaryotic cells, surface expression of most type I transmembrane proteins requires translation and simultaneous insertion of the precursor protein into the endoplasmic reticulum (ER) membrane for subsequent routing to the cell surface. This co-translational translocation pathway is initiated when a hydrophobic N-terminal signal peptide (SP) on the nascent protein emerges from the ribosome, ...
متن کاملMechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone
The virulence factor mycolactone is responsible for the immunosuppression and tissue necrosis that characterise Buruli ulcer, a disease caused by infection with Mycobacterium ulcerans In this study, we confirm that Sec61, the protein-conducting channel that coordinates entry of secretory proteins into the endoplasmic reticulum, is a primary target of mycolactone, and characterise the nature of ...
متن کاملA functional link between the co-translational protein translocation pathway and the UPR
Upon endoplasmic reticulum (ER) stress, the transmembrane endoribonuclease Ire1α performs mRNA cleavage reactions to increase the ER folding capacity. It is unclear how the low abundant Ire1α efficiently finds and cleaves the majority of mRNAs at the ER membrane. Here, we reveal that Ire1α forms a complex with the Sec61 translocon to cleave its mRNA substrates. We show that Ire1α's key substrat...
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ژورنال
عنوان ژورنال: CourseSource
سال: 2019
ISSN: 2332-6530
DOI: 10.24918/cs.2019.40